Beaufort Historic District is a historic district in Beaufort, South Carolina.

It was listed on the National Register of Historic Places in 1969, and further was declared a National Historic Landmark in 1973.

Several sites individually listed on the National Register are in Beaufort and may be contributing properties in this district. These include:

• The Anchorage (Beaufort, South Carolina)
• William Barnwell House
• Barnwell-Gough House
• John A. Cuthbert House
• Marshlands (also an NHL on its own)
• Robert Smalls House (also an NHL)
• Tabby Manse
• John Mark Verdier House